Potent Agonists Of A Hematopoietic Stem Cell

Thrombopoietin, a class I hematopoietic cytokine, plays critical roles in regulating hematopoietic stem cell numbers and also stimulates the production and differentiation of megakaryocytes, the bone marrow cells that ultimately produce platelets. Thrombopoietin interacts with the c‐Mpl cell‐surface receptor. Several growth factors feature prominently in the control of hematopoiesis. Thrombopoietin, a class I hematopoietic cytokine, plays critical roles in regulating hematopoietic stem cell numbers and also stimulates the production and differentiation of megakaryocytes, the bone marrow cells that ultimately produce platelets. Abstract Several growth factors feature prominently in the control of hematopoiesis. Thrombopoietin, a class I hematopoietic cytokine, plays critical roles in regulating hematopoietic stem cell num. is a platform for academics to share research papers. Read "Potent Agonists of a Hematopoietic Stem Cell Cytokine Receptor, c‐Mpl, ChemMedChem" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.

Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal Iman Fares, 1Jalila Chagraoui, Yves Gareau, 2Stéphane Gingras, Réjean Ruel,2 Nadine Mayotte,1 Elizabeth Csaszar,3 David J. H. F. Knapp, 4Paul Miller,4 Mor Ngom, Suzan Imren,4 Denis-Claude Roy,5,6 Kori L. Watts,7 Hans-Peter Kiem,7,8. 10/05/2016 · A short economic synthesis of pyrimidoindole derivative UM171, a potent agonist for the ex vivo expansion of hematopoietic stem cells, has been developed in this work. A unique [3,3]-sigmatropic rearrangement upon a hydroxamic precursor followed by base-promoted cyclization was successfully applied as the key step, furnishing the. Recent studies have suggested a microenvironmental contribution to stem-cell aging, but the mechanisms are largely unexplored. Méndez-Ferrer et al. report anatomical remodeling of blood-stem-cell-supporting niches and functional switch of β adrenergic signals, leading to myeloid expansion during aging. Targeting the microenvironment can.

11/10/2010 · There remains a clear need for effective tumor cell purging in autologous stem cell transplantation ASCT where residual malignant cells within the autograft contribute to disease relapse. Here we propose the use of a novel Fas agonist with potent pro-apoptotic activity, termed MegaFasL, as an effective ex-vivo purging agent. 19/09/2014 · The potent activity of these newly identified compounds, UM171 being the prototype, is independent of suppression of the aryl hydrocarbon receptor, which targets cells with more-limited regenerative potential. The properties of UM171 make it a potential candidate for hematopoietic stem cell transplantation and gene therapy. 01/12/2016 · A short economic synthesis of pyrimidoindole derivative UM171, a potent agonist for the ex vivo expansion of hematopoietic stem cells, has been developed in this work. A unique [3,3]-sigmatropic rearrangement upon a hydroxamic precursor followed by base-promoted cyclization was successfully applied as the key step, furnishing the fully functionalized indole nucleus.

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